3 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Port St. Lucie | 1 | 284,448 | 206,828 | 4.76% | 2,386 | 119 | City |
| Fort Pierce | 2 | 52,377 | 47,661 | 1.52% | 2,120 | 25 | City |
| St. Lucie Village | 3 | 617 | 610 | 0.16% | 687 | 1 | Town |
Port St. Lucie is the largest city in St. Lucie County, with a population of 284,448.
St. Lucie Village is the smallest city in St. Lucie County, with a population of 617.
There are 3 cities in St. Lucie County, Florida.