21 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Shawnee | 1 | 12,412 | 12,510 | -0.18% | 428 | 29 | Township |
| Pike | 2 | 6,678 | 6,679 | 0% | 209 | 32 | Township |
| Thorn | 3 | 4,748 | 4,551 | 0.83% | 128 | 37 | Township |
| New Lexington | 4 | 4,455 | 4,434 | 0.09% | 2,288 | 2 | Village |
| Reading | 5 | 4,439 | 4,361 | 0.38% | 88 | 50 | Township |
| Crooksville | 6 | 2,388 | 2,423 | -0.29% | 1,471 | 2 | Village |
| Bearfield | 7 | 1,484 | 1,477 | 0.2% | 54 | 27 | Township |
| Somerset | 8 | 1,466 | 1,483 | -0.2% | 1,258 | 1 | Village |
| Somerset | 9 | 1,195 | 1,244 | -0.83% | 35 | 35 | Township |
| Shawnee | 10 | 1,111 | 1,054 | 2.3% | 173 | 6 | CDP |
| Thornville | 11 | 1,097 | 1,084 | 0.27% | 2,062 | 1 | Village |
| Salt Lick | 12 | 1,081 | 1,082 | 0% | 52 | 21 | Township |
| Coal | 13 | 941 | 943 | 0% | 69 | 14 | Township |
| Pleasant | 14 | 862 | 868 | 0.12% | 54 | 16 | Township |
| Junction City | 15 | 718 | 723 | -0.14% | 1,117 | 1 | Village |
| Monday Creek | 16 | 672 | 675 | 0.15% | 27 | 25 | Township |
| New Straitsville | 17 | 649 | 654 | -0.15% | 499 | 1 | Village |
| Shawnee | 18 | 497 | 504 | -0.2% | 221 | 2 | Village |
| Corning | 19 | 482 | 489 | -0.21% | 1,121 | 0 | Village |
| Glenford | 20 | 163 | 165 | 0% | 1,442 | 0 | Village |
| Hemlock | 21 | 145 | 145 | 0% | 390 | 0 | Village |
Shawnee is the largest city in Perry County, with a population of 12,412.
Hemlock is the smallest city in Perry County, with a population of 145.
There are 21 cities in Perry County, Ohio.