5 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Nacogdoches | 1 | 32,447 | 32,115 | 0.2% | 1,175 | 28 | City |
| Garrison | 2 | 836 | 788 | 1.09% | 712 | 1 | City |
| Cushing | 3 | 582 | 560 | 0.69% | 424 | 1 | City |
| Appleby | 4 | 555 | 549 | 0.18% | 258 | 2 | City |
| Chireno | 5 | 377 | 371 | 0.27% | 201 | 2 | City |
Nacogdoches is the largest city in Nacogdoches County, with a population of 32,447.
Chireno is the smallest city in Nacogdoches County, with a population of 377.
There are 5 cities in Nacogdoches County, Texas.