5 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Belzoni | 1 | 1,668 | 1,883 | -2.11% | 1,637 | 1 | City |
| Isola | 2 | 557 | 634 | -2.28% | 754 | 1 | Town |
| Louise | 3 | 160 | 180 | -1.84% | 904 | 0 | Town |
| Silver City | 4 | 137 | 226 | -9.87% | 227 | 1 | Town |
| Eden | 5 | 135 | 132 | 0.75% | 285 | 0 | Village |
Belzoni is the largest city in Humphreys County, with a population of 1,668.
Eden is the smallest city in Humphreys County, with a population of 135.
There are 5 cities in Humphreys County, Mississippi.