5 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Belzoni | 1 | 1,681 | 1,888 | -2.38% | 1,650 | 1.02 | City |
| Isola | 2 | 562 | 632 | -2.43% | 760 | 0.74 | Town |
| Louise | 3 | 160 | 179 | -2.44% | 904 | 0.18 | Town |
| Eden | 4 | 142 | 132 | 1.43% | 300 | 0.47 | Village |
| Silver City | 5 | 121 | 225 | -14.79% | 200 | 0.60 | Town |
Belzoni is the largest city in Humphreys County, with a population of 1,681.
Silver City is the smallest city in Humphreys County.
There are 5 cities in Humphreys County, Mississippi.