6 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Macon | 1 | 2,417 | 2,575 | -1.19% | 631 | 4 | City |
| Macon | 2 | 2,417 | 2,562 | -1.19% | 631 | 4 | City |
| Brooksville | 3 | 865 | 919 | -1.14% | 544 | 2 | Town |
| Brooksville | 4 | 865 | 914 | -1.14% | 544 | 2 | Town |
| Shuqualak | 5 | 372 | 404 | -1.59% | 329 | 1 | Town |
| Shuqualak | 6 | 372 | 402 | -1.59% | 329 | 1 | Town |
Macon is the largest city in Noxubee County, with a population of 2,417.
Shuqualak is the smallest city in Noxubee County, with a population of 372.
There are 6 cities in Noxubee County, Mississippi.