3 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Waynesboro | 1 | 4,508 | 4,572 | -0.29% | 355 | 12.69 | City |
| Clara | 2 | 644 | 551 | 2.55% | 165 | 3.89 | CDP |
| Buckatunna | 3 | 98 | 360 | -22.22% | 16 | 6.18 | CDP |
Waynesboro is the largest city in Wayne County, with a population of 4,508.
Buckatunna is the smallest city in Wayne County.
There are 3 cities in Wayne County, Mississippi.