1 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Mayersville | 1 | 480 | 431 | 1.69% | 436 | 1 | Town |
Mayersville is the largest city in Issaquena County, with a population of 480.
Mayersville is the smallest city in Issaquena County, with a population of 480.
There is 1 city in Issaquena County, Mississippi.