9 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Macon | 1 | 5,523 | 5,452 | 0.25% | 911 | 6.06 | City |
| La Plata | 2 | 1,233 | 1,247 | -0.24% | 776 | 1.59 | City |
| Bevier | 3 | 626 | 635 | -0.32% | 603 | 1.04 | City |
| Atlanta | 4 | 374 | 379 | -0.27% | 1,094 | 0.34 | City |
| Callao | 5 | 246 | 250 | -0.4% | 476 | 0.52 | City |
| New Cambria | 6 | 152 | 154 | 0% | 226 | 0.67 | City |
| Elmer | 7 | 50 | 52 | 0% | 198 | 0.25 | City |
| Ethel | 8 | 48 | 48 | 0% | 208 | 0.23 | Town |
| Excello | 9 | 34 | 29 | 6.25% | 100 | 0.34 | CDP |
Macon is the largest city in Macon County, with a population of 5,523.
Excello is the smallest city in Macon County.
There are 9 cities in Macon County, Missouri.