4 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Fredericktown | 1 | 4,654 | 4,435 | 0.8% | 1,076 | 4 | City |
| Junction City | 2 | 286 | 285 | 0% | 799 | 0 | Village |
| Cobalt | 3 | 264 | 261 | 0.38% | 1,772 | 0 | Village |
| Marquand | 4 | 191 | 188 | 0.53% | 803 | 0 | City |
Fredericktown is the largest city in Madison County, with a population of 4,654.
Marquand is the smallest city in Madison County, with a population of 191.
There are 4 cities in Madison County, Missouri.