4 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Pine Ridge | 1 | 2,362 | 2,179 | 1.55% | 503 | 5 | Town |
| St. Matthews | 2 | 1,830 | 1,849 | -0.22% | 952 | 2 | Town |
| Cameron | 3 | 373 | 375 | -0.27% | 119 | 3 | Town |
| Woodford | 4 | 155 | 159 | -0.64% | 197 | 1 | Town |
Pine Ridge is the largest city in Calhoun County, with a population of 2,362.
Woodford is the smallest city in Calhoun County, with a population of 155.
There are 4 cities in Calhoun County, South Carolina.