4 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Pine Ridge | 1 | 2,368 | 2,180 | 1.63% | 504 | 4.70 | Town |
| St. Matthews | 2 | 1,817 | 1,841 | -0.27% | 945 | 1.92 | Town |
| Cameron | 3 | 368 | 375 | -0.27% | 118 | 3.13 | Town |
| Woodford | 4 | 152 | 159 | -0.65% | 194 | 0.79 | Town |
Pine Ridge is the largest city in Calhoun County, with a population of 2,368.
Woodford is the smallest city in Calhoun County.
There are 4 cities in Calhoun County, South Carolina.