9 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Easley | 1 | 27,992 | 23,034 | 3.67% | 2,128 | 13 | City |
| Clemson | 2 | 18,823 | 17,755 | 1.14% | 2,379 | 8 | City |
| Central | 3 | 5,356 | 5,270 | 0.32% | 1,647 | 3 | Town |
| Liberty | 4 | 3,342 | 3,389 | -0.3% | 689 | 5 | City |
| Pickens | 5 | 3,197 | 3,151 | 0.28% | 1,045 | 3 | City |
| Arial | 6 | 1,552 | 2,158 | -4.08% | 340 | 5 | CDP |
| Six Mile | 7 | 761 | 759 | 0% | 373 | 2 | Town |
| Norris | 8 | 755 | 747 | 0.13% | 401 | 2 | Town |
| Dacusville | 9 | 272 | 307 | 7.09% | 124 | 2 | CDP |
Easley is the largest city in Pickens County, with a population of 27,992.
Dacusville is the smallest city in Pickens County, with a population of 272.
There are 9 cities in Pickens County, South Carolina.