7 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Easley | 1 | 28,984 | 23,034 | 3.54% | 2,236 | 13 | City |
| Clemson | 2 | 19,037 | 17,755 | 1.14% | 2,406 | 8 | City |
| Central | 3 | 5,373 | 5,270 | 0.32% | 988 | 5 | Town |
| Liberty | 4 | 3,333 | 3,389 | -0.27% | 676 | 5 | City |
| Pickens | 5 | 3,206 | 3,151 | 0.28% | 1,048 | 3 | City |
| Six Mile | 6 | 762 | 759 | 0.13% | 374 | 2 | Town |
| Norris | 7 | 757 | 747 | 0.26% | 402 | 2 | Town |
Easley is the largest city in Pickens County, with a population of 28,984.
Norris is the smallest city in Pickens County, with a population of 757.
There are 7 cities in Pickens County, South Carolina.