9 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Easley | 1 | 28,620 | 23,035 | 4.06% | 2,176 | 13.15 | City |
| Clemson | 2 | 17,894 | 17,753 | 0.16% | 2,262 | 7.91 | City |
| Central | 3 | 5,358 | 5,268 | 0.34% | 1,648 | 3.25 | Town |
| Pickens | 4 | 3,385 | 3,400 | -0.09% | 1,107 | 3.06 | City |
| Liberty | 5 | 3,270 | 3,367 | -0.58% | 674 | 4.85 | City |
| Arial | 6 | 1,552 | 2,158 | -4.08% | 340 | 4.56 | CDP |
| Six Mile | 7 | 751 | 758 | -0.13% | 368 | 2.04 | Town |
| Norris | 8 | 747 | 747 | 0% | 396 | 1.88 | Town |
| Dacusville | 9 | 272 | 307 | 7.09% | 124 | 2.19 | CDP |
Easley is the largest city in Pickens County, with a population of 28,620.
Dacusville is the smallest city in Pickens County.
There are 9 cities in Pickens County, South Carolina.