11 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Lexington | 1 | 25,779 | 23,653 | 1.68% | 2,039 | 13 | Town |
| West Columbia | 2 | 18,643 | 17,516 | 1.22% | 1,989 | 9 | City |
| Cayce | 3 | 13,617 | 13,756 | -0.21% | 807 | 17 | City |
| Springdale | 4 | 2,760 | 2,740 | 0.15% | 1,021 | 3 | Town |
| South Congaree | 5 | 2,394 | 2,384 | 0.08% | 728 | 3 | Town |
| Chapin | 6 | 1,963 | 1,816 | 1.5% | 879 | 2 | Town |
| Gaston | 7 | 1,649 | 1,606 | 0.49% | 310 | 5 | Town |
| Swansea | 8 | 782 | 727 | 1.43% | 375 | 2 | Town |
| Gilbert | 9 | 628 | 577 | 1.62% | 232 | 3 | Town |
| Pelion | 10 | 621 | 628 | -0.32% | 144 | 4 | Town |
| Summit | 11 | 469 | 423 | 1.96% | 315 | 1 | Town |
Lexington is the largest city in Lexington County, with a population of 25,779.
Summit is the smallest city in Lexington County, with a population of 469.
There are 11 cities in Lexington County, South Carolina.