5 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Seneca | 1 | 9,287 | 8,860 | 0.92% | 1,097 | 8 | City |
| Walhalla | 2 | 4,291 | 4,079 | 0.99% | 1,105 | 4 | City |
| Westminster | 3 | 2,460 | 2,354 | 0.86% | 714 | 3 | City |
| West Union | 4 | 392 | 375 | 0.77% | 494 | 1 | Town |
| Salem | 5 | 129 | 119 | 1.57% | 141 | 1 | Town |
Seneca is the largest city in Oconee County, with a population of 9,287.
Salem is the smallest city in Oconee County, with a population of 129.
There are 5 cities in Oconee County, South Carolina.