16 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Orangeburg | 1 | 13,428 | 13,178 | 0.37% | 1,490 | 9 | City |
| Holly Hill | 2 | 1,250 | 1,292 | -0.71% | 715 | 2 | Town |
| Branchville | 3 | 964 | 987 | -0.52% | 304 | 3 | Town |
| Santee | 4 | 810 | 830 | -0.49% | 324 | 3 | Town |
| Bowman | 5 | 763 | 782 | -0.52% | 648 | 1 | Town |
| North | 6 | 673 | 691 | -0.59% | 779 | 1 | Town |
| Elloree | 7 | 543 | 567 | -0.91% | 511 | 1 | Town |
| Springfield | 8 | 434 | 449 | -0.69% | 250 | 2 | Town |
| Neeses | 9 | 314 | 319 | -0.32% | 184 | 2 | Town |
| Norway | 10 | 273 | 285 | -1.09% | 345 | 1 | Town |
| Rowesville | 11 | 251 | 251 | 0% | 301 | 1 | Town |
| Eutawville | 12 | 241 | 238 | 0% | 253 | 1 | Town |
| Cordova | 13 | 129 | 136 | -1.53% | 296 | 0 | Town |
| Livingston | 14 | 127 | 131 | -0.78% | 161 | 1 | Town |
| Vance | 15 | 123 | 127 | -0.81% | 243 | 1 | Town |
| Cope | 16 | 31 | 33 | -3.13% | 124 | 0 | Town |
Orangeburg is the largest city in Orangeburg County, with a population of 13,428.
Cope is the smallest city in Orangeburg County, with a population of 31.
There are 16 cities in Orangeburg County, South Carolina.