19 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Orangeburg | 1 | 13,353 | 13,170 | 0.28% | 1,482 | 9 | City |
| Brookdale | 2 | 3,868 | 4,740 | -1.7% | 1,062 | 4 | CDP |
| Wilkinson Heights | 3 | 1,776 | 1,863 | -2.58% | 594 | 3 | CDP |
| Edisto | 4 | 1,740 | 1,993 | -3.06% | 330 | 5 | CDP |
| Holly Hill | 5 | 1,229 | 1,286 | -0.89% | 940 | 1 | Town |
| Branchville | 6 | 960 | 987 | -0.52% | 303 | 3 | Town |
| Santee | 7 | 799 | 831 | -0.75% | 319 | 3 | Town |
| Bowman | 8 | 755 | 780 | -0.66% | 641 | 1 | Town |
| North | 9 | 666 | 691 | -0.75% | 771 | 1 | Town |
| Elloree | 10 | 538 | 567 | -1.1% | 506 | 1 | Town |
| Springfield | 11 | 426 | 448 | -0.93% | 245 | 2 | Town |
| Neeses | 12 | 309 | 319 | -0.64% | 181 | 2 | Town |
| Norway | 13 | 271 | 283 | -0.73% | 342 | 1 | Town |
| Rowesville | 14 | 243 | 250 | -0.41% | 291 | 1 | Town |
| Eutawville | 15 | 233 | 237 | -0.43% | 245 | 1 | Town |
| Cordova | 16 | 129 | 138 | -1.53% | 296 | 0 | Town |
| Livingston | 17 | 126 | 130 | -0.79% | 160 | 1 | Town |
| Vance | 18 | 122 | 126 | -0.81% | 241 | 1 | Town |
| Cope | 19 | 31 | 33 | 0% | 124 | 0 | Town |
Orangeburg is the largest city in Orangeburg County, with a population of 13,353.
Cope is the smallest city in Orangeburg County, with a population of 31.
There are 19 cities in Orangeburg County, South Carolina.