16 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Orangeburg | 1 | 13,478 | 13,178 | 0.37% | 1,496 | 9 | City |
| Holly Hill | 2 | 1,242 | 1,292 | -0.64% | 710 | 2 | Town |
| Branchville | 3 | 960 | 987 | -0.41% | 303 | 3 | Town |
| Santee | 4 | 806 | 830 | -0.49% | 322 | 3 | Town |
| Bowman | 5 | 759 | 782 | -0.52% | 645 | 1 | Town |
| North | 6 | 670 | 691 | -0.45% | 775 | 1 | Town |
| Elloree | 7 | 538 | 567 | -0.92% | 506 | 1 | Town |
| Springfield | 8 | 431 | 449 | -0.69% | 248 | 2 | Town |
| Neeses | 9 | 313 | 319 | -0.32% | 183 | 2 | Town |
| Norway | 10 | 271 | 285 | -0.73% | 342 | 1 | Town |
| Rowesville | 11 | 251 | 251 | 0% | 301 | 1 | Town |
| Eutawville | 12 | 242 | 238 | 0.41% | 254 | 1 | Town |
| Cordova | 13 | 128 | 136 | -0.78% | 294 | 0 | Town |
| Livingston | 14 | 126 | 131 | -0.79% | 160 | 1 | Town |
| Vance | 15 | 122 | 127 | -0.81% | 241 | 1 | Town |
| Cope | 16 | 31 | 33 | 0% | 124 | 0 | Town |
Orangeburg is the largest city in Orangeburg County, with a population of 13,478.
Cope is the smallest city in Orangeburg County, with a population of 31.
There are 16 cities in Orangeburg County, South Carolina.