19 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Orangeburg | 1 | 13,428 | 13,178 | 0.37% | 1,490 | 9 | City |
| Brookdale | 2 | 3,868 | 4,740 | -1.7% | 1,062 | 4 | CDP |
| Wilkinson Heights | 3 | 1,776 | 1,863 | -2.58% | 594 | 3 | CDP |
| Edisto | 4 | 1,740 | 1,993 | -3.06% | 330 | 5 | CDP |
| Holly Hill | 5 | 1,250 | 1,292 | -0.71% | 956 | 1 | Town |
| Branchville | 6 | 964 | 987 | -0.52% | 304 | 3 | Town |
| Santee | 7 | 810 | 830 | -0.49% | 324 | 3 | Town |
| Bowman | 8 | 763 | 782 | -0.52% | 648 | 1 | Town |
| North | 9 | 673 | 691 | -0.59% | 779 | 1 | Town |
| Elloree | 10 | 543 | 567 | -0.91% | 511 | 1 | Town |
| Springfield | 11 | 434 | 449 | -0.69% | 250 | 2 | Town |
| Neeses | 12 | 314 | 319 | -0.32% | 184 | 2 | Town |
| Norway | 13 | 273 | 285 | -1.09% | 345 | 1 | Town |
| Rowesville | 14 | 251 | 251 | 0% | 301 | 1 | Town |
| Eutawville | 15 | 241 | 238 | 0% | 253 | 1 | Town |
| Cordova | 16 | 129 | 136 | -1.53% | 296 | 0 | Town |
| Livingston | 17 | 127 | 131 | -0.78% | 161 | 1 | Town |
| Vance | 18 | 123 | 127 | -0.81% | 243 | 1 | Town |
| Cope | 19 | 31 | 33 | -3.13% | 124 | 0 | Town |
Orangeburg is the largest city in Orangeburg County, with a population of 13,428.
Cope is the smallest city in Orangeburg County, with a population of 31.
There are 19 cities in Orangeburg County, South Carolina.